Dolutegravir O-β-D-Glucuronide

Catalogue number: D528810
Chemical name: Dolutegravir O-β-D-Glucuronide
Synonyms: (4R,12aS)-9-[[[(2,4-Difluorophenyl)methyl]amino]carbonyl]-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazin-7-yl β-D-Glucopyranosiduronic Acid
CAS Number: 1485692-21-4
Possible CAS #: NA
Molecular form.: C₂₆H₂₇F₂N₃O₁₁
Appearance: White Solid
Melting Point: 122-124°C
Mol. Weight: 595.5
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Methanol (Slightly), Water (Slightly)
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: Dolutegravir O-β-D-Glucuronide is a metabolite of Dolutegravir (D528800); a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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  Pack size Price(USD)
1mg $140.00
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10mg $1120.00
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  Pack size Price(USD)
5mg $625.00
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25mg $2600.00
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Exact Weight Packaging ($75(USD) / Vial)
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