Catalogue number: D528802
Chemical name: Dolutegravir-d4
Synonyms: (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1’,2’:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide-d4; GSK 1349572-d4; S/GSK1349572-d4;
CAS Number: NA
Possible CAS #: Unlabelled: 1051375-16-6
Molecular form.: C₂₀H₁₅D₄F₂N₃O₅
Appearance: Off-White to Pale Beige Solid
Melting Point: >160°C (dec.)
Mol. Weight: 423.4
Storage: Refrigerator
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Anti-virals, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Isotope labelled Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Dangerous Goods Info: NA
References: Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);
Peer Review Product Citations:

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  Pack size Price(USD)
.25mg $250.00
10mg $6250.00
  Pack size Price(USD)
1mg $875.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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