L,L-Dityrosine Dihydrochloride

Catalogue number: D494290
Chemical name: L,L-Dityrosine Dihydrochloride
Synonyms: (α3S,α3’S)-α3,α3’-Diamino-6,6’-dihydroxy-[1,1’-biphenyl]-3,3’-dipropanoic Acid Dihydrochloride; [S-(R*,R*)]- α,α’-Diamino-6,6’-dihydroxy-[1,1’-biphenyl]-3,3’- dipropanoic Acid Dihydrochloride; 3,3’-Bityrosine Dihydrochloride; 3,3’-Dityrosine Dihydrochloride; Bityrosine Dihydrochloride; Dityrosine Dihydrochloride; o,o-Dityrosine Dihydrochloride; o,o’-Dityrosine Dihydrochloride;
CAS Number: 221308-01-6
Possible CAS #: 63442-81-9-free base
Molecular form.: C₁₈H₂₂Cl₂N₂O₆
Appearance: White to Off-White Solid
Melting Point: >210°C (dec.)
Mol. Weight: 433.28
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Methanol, Water
Stability: No Data Available
Category: Amines, Aromatics, Fluorescent Labels & Indicators, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Dityrosine (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.
Dangerous Goods Info: NA
References: Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),
Peer Review Product Citations:

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