Dimethyloxaloylglycine

Catalogue number: D476325
Chemical name: Dimethyloxaloylglycine
Synonyms: N-[(Methoxycarbonyl)methyl]oxamic Acid Methyl Ester; N-(methoxyoxoacetyl)glycine Methyl Ester; DMOG;
CAS Number: 89464-63-1
Possible CAS #: NA
Molecular form.: C₆H₉NO₅
Appearance: Off-White to Pale Pink Solid
Melting Point: 46-48°C
Mol. Weight: 175.14
Storage: Refrigerator
Solubility: DMSO, Ethanol, Methanol
Stability: No Data Available
Category: Amino Acids & Derivatives, Inhibitors
Boiling Point: No Data Available
Applications: DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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Inventory Status:   Pending QC

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