Catalogue number: D454925
Chemical name: (2R,3S,11bR)-Dihydrotetrabenazine
Synonyms: (2R,3S,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
CAS Number: 862377-31-9
Possible CAS #: NA
Molecular form.: C₁₉H₂₉NO₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 319.44
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: (2R,3S,11bR)-Dihydrotetrabenazine is an enantiomer of (2S,3R,11bS)-Dihydrotetrabenazine (D454920). Tetrabenazine and dihydrotetrabenazines are potent inhibitors of vesicular monoamine transporter 2 (VMAT2). Furthermore, the derivatives of these compounds are potential drug candidates for treating various diseases such as Huntington’s disease and other hyperkinetic disorders. 
Dangerous Goods Info: NA
References: Yao, Z., et al.: Eur. J. Med. Chem. 46, 1841 (2011); Duffield, A. J. and Williams, N. A. PCT Int. Appl. WO 2010026434 A1 20100311(2010); Grayson, B. et al.: PCT Int. Appl. WO 2009150474 A1 20091217 (2009); Nichols, P. P. Brit. UK Pat. Appl. GB 2463451 A 20100317 (2010)
Peer Review Product Citations:

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