Catalogue number: D452282
Chemical name: trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene-d8
Synonyms: (7R,8R)-rel-7,8-Dihydrobenzo[a]pyrene-1,2,3,4,5,6,11,12-d8-7,8-diol
CAS Number: 861441-06-7
Possible CAS #: Unlabelled: 60864-95-1
Molecular form.: C₂₀H₆D₈O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 294.37
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Isotope Labelled Compounds, Mutagenesis Research Chemicals
Boiling Point: No Data Available
Applications: Labelled trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2’-deoxyguanosine. A carcinogen.
Dangerous Goods Info: NA
References: Gelhaus, S. et al: Chem. Res. Toxicol., 24, 89 (2011); Belvedere, G. et al.: Biochem. Pharmacol., 29, 1693 (1980); Jennette, K. et al.: Biochem. Pharmacol., 28, 338 (1979); Yagi, H. et al.: J. Am. Chem. Soc., 99, 2358 (1977)
Peer Review Product Citations:

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