N,N’-Di-Boc-S-di(trityl)-di-O-cysteinyl-glycinoyl Curcumin

Catalogue number: D420025
Chemical name: N,N’-Di-Boc-S-di(trityl)-di-O-cysteinyl-glycinoyl Curcumin
Synonyms: 4-((1E,6E)-7-(4-(2-((R)-2-((Tert-butoxycarbonyl)amino)-3-(tritylthio)propanamido)acetoxy)-3-methoxyphenyl)-3,5-dioxohepta-1,6-dien-1-yl)-2-methoxyphenyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-(tritylthio)propanamido)acetate
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₇₉H₈₀N₄O₁₄S₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 1373.63
Storage: No Data Available
Solubility: Chloroform, Ethyl Acetate
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: N,N’-Di-boc-S-di(trityl)-di-O-cysteinyl-glycinoyl Curcumin is an intermediate of Di-O-cysteinyl-glycinoyl Curcumin (D455600). Di-O-cysteinyl-glycinoyl curcumin is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticul
Dangerous Goods Info: NA
References: Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)
Peer Review Product Citations:

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  Pack size Price(USD)
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5mg $515.00
  Pack size Price(USD)
2.5mg $275.00
10mg $950.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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