N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

Catalogue number: D292043
Chemical name: N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
Synonyms: 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E/Z)-Endoxifen; 4OHNDtam;
CAS Number: 110025-28-0
Possible CAS #: 112093-28-4-for Z
Molecular form.: C₂₅H₂₇NO₂
Appearance: Light Brown to Light Purple Solid
Melting Point: 69-74°C
Mol. Weight: 373.49
Storage: -20°C Freezer
Solubility: Chloroform, Dichloromethane, DMSO, Methanol
Stability: No Data Available
Category: Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
Dangerous Goods Info: NA
References: Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),
Peer Review Product Citations:

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  Pack size Price(USD)
5mg $150.00
  Pack size Price(USD)
50mg $1200.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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