N-Des(4-methylbenzenesulfonamide) 4’-Nitro Tolafentrine

Catalogue number: D291140
Chemical name: N-Des(4-methylbenzenesulfonamide) 4’-Nitro Tolafentrine
Synonyms: (10bS)-8,9-Dimethoxy-2-methyl-6-(4-nitrophenyl)-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridine; cis-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methyl-6-(4-nitrophenyl)-benzo[c][1,6]naphthyridine
CAS Number: 35134-99-7
Possible CAS #: NA
Molecular form.: C₂₁H₂₃N₃O₄
Appearance: Yellow Solid
Melting Point: No Data Available
Mol. Weight: 381.43
Storage: No Data Available
Solubility: Dichloromethane(Partial), Dimethylformamide, Methanol
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: N-Desmethylbenzenesulfonamide 4’-Nitro Tolafentrine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
Dangerous Goods Info: NA
References: Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),
Peer Review Product Citations:

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  Pack size Price(USD)
.5mg $225.00
5mg $1995.00
  Pack size Price(USD)
2.5mg $1050.00
10mg $3775.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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