3-Descarbonitrile 3-Acetamido Saxagliptin

Catalogue number: D291060
Chemical name: 3-Descarbonitrile 3-Acetamido Saxagliptin
Synonyms: (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo [,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carboxamide
CAS Number: 1496712-39-0
Possible CAS #: NA
Molecular form.: C₁₈H₂₇N₃O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 333.43
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 3-Descarbonitrile 3-Acetamido Saxagliptin is a Saxagliptin (S143500) impurity, a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
Dangerous Goods Info: NA
References: Feng, J., et al.: J. Med. Chem., 50, 2297 (2007), Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008), Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008),
Peer Review Product Citations:

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