5-Desfluoro Sitagliptin

Catalogue number: D290365
Chemical name: 5-Desfluoro Sitagliptin
Synonyms: (R)-3-Amino-4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one-phosphate
CAS Number: 1345822-86-7
Possible CAS #: NA
Molecular form.: C₁₆H₁₉F₅N₅O₅P
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 487.32
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: 5-Desfluoro Sitagliptin is a metabolite of Sitagliptin phosphate (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
Dangerous Goods Info: NA
References: Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)
Peer Review Product Citations:

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