(2’R)-2’-Deoxy-3’,5’-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine

Catalogue number: D233020
Chemical name: (2’R)-2’-Deoxy-3’,5’-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine
Synonyms:
CAS Number: 1393526-40-3
Possible CAS #: NA
Molecular form.: C₂₂H₄₁FN₂O₅Si₂
Appearance: Pale Yellow Oil
Melting Point: No Data Available
Mol. Weight: 488.74
Storage: No Data Available
Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: (2’R)-2’-Deoxy-3’,5’-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2’-fluoro-2’-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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Inventory Status:   Pending QC

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