2-Deoxy-D-erythro-pentopyranosyl Chloride Bis(4-methylbenzoate) (Decitabine Impurity) (Mixture of α/β isomers)

Catalogue number: D232935
Chemical name: 2-Deoxy-D-erythro-pentopyranosyl Chloride Bis(4-methylbenzoate) (Decitabine Impurity) (Mixture of α/β isomers)
CAS Number: 20535-28-8
Possible CAS #: α-Isomer: 20535-28-8/ β-Isomer: 516511-18-5
Molecular form.: C₂₁H₂₁ClO₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 388.84
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Carbohydrates and Derivatives, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates and Fine Chemicals
Boiling Point: No Data Available
Applications: 2-Deoxy-D-erythro-pentopyranosyl chloride bis(4-methylbenzoate) is an impurity of Decitabine (α-isomer: D226730), a DNA hypomethylating agent that is used to treat various forms of cancer, such as myelogeneous leukemia and metastatic lung cancerBy inhibiting DNA methyltransferase, Decitabine silences the tumour suppressor genes and, consequently, “normalizing” gene expression in cancerous cells.
Dangerous Goods Info: NA
References: Aribi, A., et al.: Cancer, 109, 713 (2007); Issa, J., et al.: Blood, 103, 1635 (2004); Kantarjian , H., et al.: Cancer, 98, 522 (2003); Momparler, R., et al.: Anti-Cancer Drug., 8, 358 (1997); Plimack, E., et al.: Leukemia Lymphoma, 48, 1472 (2007)
Peer Review Product Citations:

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