N-Deacetyl Colchiceine

Catalogue number: D198900
Chemical name: N-Deacetyl Colchiceine
Synonyms: (7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo[a]heptalen-9(5H)-one; NSC 36796; Trimethylcolchicinic Acid;
CAS Number: 3482-37-9
Possible CAS #: NA
Molecular form.: C₁₉H₂₁NO₅
Appearance: Light Yellow to Light Green Solid
Melting Point: >201˚C (dec.)
Mol. Weight: 343.37
Storage: -20˚C Freezer
Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly)
Stability: No Data Available
Category: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Dangerous Goods Info: NA
References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998), Tanaka, H., et al.: Canc. Res., 69, 6978 (2009), D’Elia, M., et al.: Chem. Biol., 16, 548 (2009),
Peer Review Product Citations:

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Inventory Status:   Pending QC

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