L-​Cysteinyl-​L-​cysteinyl-​L-​α-​glutamyl-​L-​tyrosyl-​L-​cysteinyl-​L-​cysteinyl-​L-​asparaginyl-​L-​prolyl-​L-​alanyl-​L-​cysteinyl-​L-​threonylglycyl-​L-​cysteinyl-L-​Tyrosine Trifluoroacetate

Catalogue number: C994760
Chemical name: L-​Cysteinyl-​L-​cysteinyl-​L-​α-​glutamyl-​L-​tyrosyl-​L-​cysteinyl-​L-​cysteinyl-​L-​asparaginyl-​L-​prolyl-​L-​alanyl-​L-​cysteinyl-​L-​threonylglycyl-​L-​cysteinyl-L-​Tyrosine Trifluoroacetate
Synonyms: Linaclotide Linear Trifluoroacetate
CAS Number: 1638632-09-3
Possible CAS #: 742095-77-8 free amine
Molecular form.: C₆₁H₈₆F₃N₁₅O₂₃S₆
Appearance: White Solid
Melting Point: >192°C (dec.)
Mol. Weight: 1646.81
Storage: -20°C Freezer, Under inert atmosphere
Solubility: DMSO, Water
Stability: No Data Available
Category: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: L-​Cysteinyl-​L-​cysteinyl-​L-​α-​glutamyl-​L-​tyrosyl-​L-​cysteinyl-​L-​cysteinyl-​L-​asparaginyl-​L-​prolyl-​L-​alanyl-​L-​cysteinyl-​L-​threonylglycyl-​L-​cysteinyl-L-​Tyrosine is a derivative of Linaclotide (L465880), a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
Dangerous Goods Info: NA
References: Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012)
Peer Review Product Citations:

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