Catalogue number: C785002
Chemical name: Crizotinib-d5
Synonyms: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine-d5; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine-d5; PF 02341066-d5; PF 2341066-d5; [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-yl]amine-d5;
CAS Number: 1395950-48-7
Possible CAS #: unlabelled: 877399-52-5
Molecular form.: C₂₁H₁₇D₅Cl₂FN₅O
Appearance: White to Light Tan Solid
Melting Point: 198-199°C (dec.)
Mol. Weight: 455.37
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Aromatic, Chiral Reagents, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Labelled Crizotinib(C785000). A potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Dangerous Goods Info: NA
References: Zou, H.Y. et al.: Cancer Res., 67, 4408 (2007); Cui, J.J. et al.: J. Med. Chem., No pp given (2011); Sasaki, T. et al.: Cancer. Res. et al.: 70, 10038 (2010);
Peer Review Product Citations:

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