Crenolanib Trifluoroacetic Acid Salt

Catalogue number: C781800
Chemical name: Crenolanib Trifluoroacetic Acid Salt
Synonyms: 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine Trifluoroacetic Acid Salt; ARO 002 Trifluoroacetic Acid Salt; CP 868596 Trifluoroacetic Acid Salt; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Trifluoroacetic Acid Salt;
CAS Number: 1797008-57-1
Possible CAS #: Free amine: 670220-88-9
Molecular form.: C₂₈H₃₀F₃N₅O₄
Appearance: White to Off-White Solid
Melting Point: 217-220°C
Mol. Weight: 557.56
Storage: Refrigerator
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors,
Boiling Point: No Data Available
Applications: Crenolanib (CP-868569) is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFRβ. Crenolanib (CP-868569) inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type PDGFRα. Crenolanib (CP-868569) possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation.
Dangerous Goods Info: NA
References: Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);
Peer Review Product Citations: Michael, M. et al.: Br. J. Cancer, 103, 1554 (2010); Lewis, N.L. et al.: J. Clin. Oncol., 27, 5262 (2009);

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  Pack size Price(USD)
5mg $95.00
50mg $375.00
200mg $945.00
  Pack size Price(USD)
10mg $145.00
100mg $615.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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