Clasto-lactacystin (Omuralide)

Catalogue number: C562500
Chemical name: Clasto-lactacystin (Omuralide)
Synonyms: (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Clasto-lactacystin β-Lactone; Omuralide
CAS Number: 154226-60-5
Possible CAS #: NA
Molecular form.: C₁₀H₁₅NO₄
Appearance: White Solid
Melting Point: 186-187°C
Mol. Weight: 213.23
Storage: -20°C Freezer
Solubility: DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
Stability: No Data Available
Category: Inhibitors
Boiling Point: No Data Available
Applications: A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Dangerous Goods Info: NA
References: Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)
Peer Review Product Citations:

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  Pack size Price(USD)
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500µg $450.00
  Pack size Price(USD)
100µg $110.00
1mg $800.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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