4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate

Catalogue number: C422245
Chemical name: 4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate
Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]- N’-[4-[[(4-Chloro-3-(trifluoromethyl)phenylamino)carbonyl]oxy]-2-fluorophenyl]-Urea
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₂₂H₁₂Cl₂F₇N₃O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 570.24
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: 4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate is an impurity of Regorafenib (R143000), which inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Dangerous Goods Info: NA
References: Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)
Peer Review Product Citations: Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

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