Catalogue number: C379830
Chemical name: (R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Synonyms: (2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide; Avagacestat; BMS 708163; BMS 708163-01;
CAS Number: 1146699-66-2
Possible CAS #: NA
Molecular form.: C₂₀H₁₇ClF₄N₄O₄S
Appearance: White Solid
Melting Point: 157-160°C
Mol. Weight: 520.88
Storage: Refrigerator
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Avagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.
Dangerous Goods Info: NA
References: Harris, PJ. et al.: Expert. Opin. Ther. Tar., 16, 131 (2012); Gilman, K.W. et al.: ACS Med. Chem. Lett., 1, 120 (2010);
Peer Review Product Citations:

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