Catalogue number: C377695
Chemical name: 5-Chloro-2-nitroanisole
Synonyms: 4-Chloro-2-methoxy-1-nitrobenzene; 5-Chloro-2-nitroanisole; 1-Chloro-3-methoxy-4-nitrobenzene; 2-Methoxy-4-chloronitrobenzene; 2-Nitro-5-chloroanisole; 3-Methoxy-4-nitro-1-chlorobenzene; 4-Chloro-2-(methyloxy)-1-nitrobenzene; 4-Chloro-2-methoxy-1-nitrobenzene; 4-Chloro-2-methoxynitrobenzene; 5-Chloro-2-nitroanisole; 5-Chloro-2-nitrophenyl Methyl Ether; NSC 60112
CAS Number: 6627-53-8
Possible CAS #: NA
Molecular form.: C₇H₆ClNO₃
Appearance: Yellow Solid
Melting Point: 71-73°C
Mol. Weight: 187.58
Storage: Refrigerator
Solubility: Chloroform, Ethyl Acetate
Stability: No Data Available
Category: Aromatics, Miscellaneous Reagents,
Boiling Point: No Data Available
Applications: 5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs. In addition it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells.
Dangerous Goods Info: NA
References: Mesaros, E. et al.: J. Med. Chem., 55, 115 (2012); Diamond, M. et al.: J. Med. Chem., 50, 4939 (2007);
Peer Review Product Citations: Mesaros, E. et al.: J. Med. Chem., 55, 115 (2012); Diamond, M. et al.: J. Med. Chem., 50, 4939 (2007);

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50g $500.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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