2-Chloro-5-nitro-N-4-pyridinylbenzamide

Catalogue number: C374760
Chemical name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Synonyms: T0070907
CAS Number: 313516-66-4
Possible CAS #: NA
Molecular form.: C₁₂H₈ClN₃O₃
Appearance: Light Orange Solid
Melting Point: >184°C (dec.)
Mol. Weight: 277.66
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Inhibitors
Boiling Point: No Data Available
Applications: A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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