CHIR-99021 Hydrochloride

Catalogue number: C292150
Chemical name: CHIR-99021 Hydrochloride
Synonyms: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride;
CAS Number: 1797989-42-4
Possible CAS #: Free Base: 252917-06-9
Molecular form.: C₂₂H₁₉Cl₃N₈
Appearance: Off-White to Pale Beige Solid
Melting Point: >238°C (dec.)
Mol. Weight: 501.8
Storage: Hygroscopic, Refrigerator, Under Inert Atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
Dangerous Goods Info: NA
References: Ring, et al.: Diabetes, 52, 588 (2003); Tighe, et al.: Cell Biol., 8, 34 (2007); Pan, et al.: Neuropsychopharmacology, 36, 1397 (2011);
Peer Review Product Citations:

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  Pack size Price(USD)
10mg $175.00
  Pack size Price(USD)
100mg $1400.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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