Catalogue number: C249500
Chemical name: Celastrol
Synonyms: 3-Hydroxy-2-oxo-24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid; Tripterin; Tripterine (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid;
CAS Number: 34157-83-0
Possible CAS #: NA
Molecular form.: C₂₉H₃₈O₄
Appearance: Orange Red Solid
Melting Point: 187-189°C
Mol. Weight: 450.61
Storage: -20°C Freezer
Solubility: DMSO, Chloroform, Methanol
Stability: No Data Available
Category: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
Boiling Point: No Data Available
Applications: An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. Celastrol is also a leptin sensitizer with the potential to reduce weight in obesity (see W499200).
Dangerous Goods Info: NA
References: Senger, D., et al.: Science, 219, 983 (1983), Folkman, J., et al.: Nature, 1, 27 (1995), He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1998), Grosios, K., et al.: Inflamm. Res., 53, 133 (2004), Yang, H., et al.: Cancer Res., 66, 4758 (2006); AAPS Newsmagazine p. 17, July 2016; Chem. and Eng. News p. 6, Aug. 8, 2016
Peer Review Product Citations:

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50mg $295.00
Exact Weight Packaging ($75(USD) / Vial)
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