Catalogue number: C227900
Chemical name: CCT036477
Synonyms: α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine;
CAS Number: 305372-78-5
Possible CAS #: NA
Molecular form.: C₂₁H₁₈ClN₃
Appearance: Off-White to Pale Beige Solid
Melting Point: >167°C (dec.)
Mol. Weight: 347.84
Storage: Amber Vial, Refrigerator, Under inert atmosphere
Solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
Stability: No Data Available
Category: Aromatics, Heterocycles, Indole Deribatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
Dangerous Goods Info: NA
References: Ewan, K. et al.: Cancer Res., 14, 5963 (2010);
Peer Review Product Citations:

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  Pack size Price(USD)
25mg $140.00
  Pack size Price(USD)
250mg $1120.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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