m-Carboxycinnamic Acid Bishydroxamide

Catalogue number: C177840
Chemical name: m-Carboxycinnamic Acid Bishydroxamide
Synonyms: N-Hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]benzamide; CBHA;
CAS Number: 174664-65-4
Possible CAS #: NA
Molecular form.: C₁₀H₁₀N₂O₄
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 222.2
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Histone deacetylase inhibitor II. A cell-permeable second generation hybrid polar agent that inhibits HDAC activity. Inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Induces apoptosis and Fas/Fas ligand expression in human neuroblastoma.
Dangerous Goods Info: NA
References: Yoshida, M., et al.: J. Biol. Chem., 265, 17174 (1990), Lee, B., et al.: Cancer Res., 61, 931 (2001), Takai, N., et al.: Clin. Cancer Res., 10, 1141 (2004), Ryan, Q., et al.: J. Clin. Oncol., 23, 3912 (2005), Rahnama, F., et al.: Endocrinology, 147, 5275 (2006),
Peer Review Product Citations:

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Exact Weight Packaging ($75(USD) / Vial)
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