Catalogue number: C175145
Chemical name: (R)-(-)-Camptothecin
Synonyms: (R)-4-Ethyl-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (R)-(-)-Camptothecine; (R)-Camptothecin; 20R-Camptothecin;
CAS Number: 110351-92-3
Possible CAS #: NA
Molecular form.: C₂₀H₁₆N₂O₄
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 348.33
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
Dangerous Goods Info: NA
References: Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998),
Peer Review Product Citations:

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