tert-Butyl (1R,3R,5R)-3-Carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate

Catalogue number: B692930
Chemical name: tert-Butyl (1R,3R,5R)-3-Carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate
Synonyms: (1R,3R,5R)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic Acid 1,1-Dimethylethyl Ester
CAS Number: 1564266-54-1
Possible CAS #: NA
Molecular form.: C₁₁H₁₈N₂O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 226.27
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: tert-Butyl (1R,3R,5R)-3-Carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate is an intermediate in the synthesis of (2’R,2R,cis)-Saxagliptin (S143475), which is an impurity of Saxagliptin (S143500). Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4 (DPP-IV) developed for the treatment of type 2 diabetes.
Dangerous Goods Info: NA
References: Dong, J., et al.: Bioorg. Med. Chem., 22, 1383 (2014); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007); Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008); Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008)
Peer Review Product Citations:

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