tert-Butyl-4-hydroxy Atorvastatin-d5

Catalogue number: B692347
Chemical name: tert-Butyl-4-hydroxy Atorvastatin-d5
Synonyms: (3R,5R)-tert-Butyl 7-(2-(4-Fluorophenyl)-4-((4-hydroxyphenyl)carbamoyl)-5-isopropyl-3-phenyl-d5-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₃₇H₃₈D₅FN₂O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 635.78
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: tert-Butyl-4-hydroxy Atorvastatin-d5 is the labeled analogue of tert-Butyl-4-hydroxy Atorvastatin (B692345), an intermediate in the synthesis of 4-Hydroxy Atorvastatin Hemicalcium Salt (H828961), a hydroxylated metabolite of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Dangerous Goods Info: NA
References: Smith, S. et al.: Am. J. Cardiol., 80, 10H (1997); Jacobsen, W. et al.: Drug Metab. Dispos., 28, 1369 (2000); Istvan, E. et al.: Science, 292, 1160 (2001); Tabernero, L. et al.: J. Biol. Chem., 278, 19933 (2003); Bratton, L. et al.: Bioorg. Med. Chem., 15, 5576 (2007); Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)
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