42-O-tert-Butyldimethylsilyloxyethyl Rapamycin

Catalogue number: B691475
Chemical name: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin
Synonyms: 42-O-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]rapamycin; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine Rapamycin Deriv.; Everolimus tert-Butyldimethylsilyl Ether
CAS Number: 159351-68-5
Possible CAS #: NA
Molecular form.: C₅₉H₉₇NO₁₄Si
Appearance: White to Off-White Solid
Melting Point: >93°C (dec.)
Mol. Weight: 1072.49
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400); an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.
Dangerous Goods Info: NA
References: Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Venkata, S.P., et al.: PCT Int. Appl. WO 2012066502 A1 20120524. May 24, 2012
Peer Review Product Citations:

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25mg $335.00
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100mg $1275.00
Exact Weight Packaging ($75(USD) / Vial)
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