Catalogue number: B656425
Chemical name: Boc-3-hydroxy-1-adamantyl-L-glycine
Synonyms: (2R)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic Acid; (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxy-tricyclo[,7]decane-1-acetic Acid
CAS Number: 1334321-39-9
Possible CAS #: NA
Molecular form.: C₁₇H₂₇NO₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 325.4
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: Boc-3-hydroxy-1-adamantyl-L-glycine is an impurity of Saxagliptin (S143500), which is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
Dangerous Goods Info: NA
References: Feng, J., et al.: J. Med. Chem., 50, 2297 (2007), Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008), Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008),
Peer Review Product Citations:

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