Catalogue number: B648220
Chemical name: Boc-3,5-dihydroxy-1-adamantyl-L-glycine
Synonyms: (S)-2-((tert-Butoxycarbonyl)amino)-2-((1r,3R,5S,7S)-3,5-dihydroxyadamantan-1-yl)acetic Acid; (αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-3,5-dihydroxytricyclo[,7]decane-1-acetic Acid
CAS Number: 681282-72-4
Possible CAS #: NA
Molecular form.: C₁₇H₂₇NO₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 341.4
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amino Acids & Derivatives, Chiral Reagents
Boiling Point: No Data Available
Applications: Boc-3,5-dihydroxy-1-adamantyl-L-glycine is a reactant in the synthesis of of Saxagliptin (S143500), a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
Dangerous Goods Info: NA
References: Augeri, D.J., et. al.: J. Med. Chem., 48, 5025 (2005); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007); Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008); Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008)
Peer Review Product Citations:

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