BMS 181174-d4

Catalogue number: B595912
Chemical name: BMS 181174-d4
Synonyms: (1aS,8R,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione-d4; [1aS-(1aα,8β,8aα,8bα)]-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione-d4; BMY 25067-d4; N-7-(2-Nitrophenyldithio)ethyl)mitomycin C-d4
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₂₃H₂₁D₄N₅O₇S₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 551.63
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: BMS 181174-d4 is labelled BMS 181174 (B595910), an analog of Mitomycin C (M371900) with activity against a range of tumour cell lines and xenografts, including MMC-resistant tumours. However, phase I clinical trials from Bristol-Myers Squibb demonstrated that the toxicity profile of BMS 181174 was no more favourable than that of mitomycin.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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