Catalogue number: B592495
Chemical name: (R)-(+)-Blebbistatin
Synonyms: (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (+)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; (+)-Blebbistatin;
CAS Number: 1177356-70-5
Possible CAS #: NA
Molecular form.: C₁₈H₁₆N₂O₂
Appearance: Bright Yellow Solid
Melting Point: 210-212°C
Mol. Weight: 292.33
Storage: -20˚C Freezer
Solubility: Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol
Stability: No Data Available
Category: Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM. A negative control for the (S)-(-)-Blebblastatin. [a]D= +110 (c= 1.21 CHCl3) (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
Dangerous Goods Info: NA
References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)
Peer Review Product Citations:

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  Pack size Price(USD)
1mg $45.00
10mg $205.00
50mg $905.00
  Pack size Price(USD)
5mg $110.00
25mg $485.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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