1,11-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]- cyclotetradecane

Catalogue number: B585395
Chemical name: 1,11-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]- cyclotetradecane
Synonyms: Plerixafor Impurity III;
CAS Number: 771464-86-9
Possible CAS #: NA
Molecular form.: C₄₆H₈₄N₁₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 805.24
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 1,11-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-cyclotetradecane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM).
References: Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007);
Dangerous Goods Info: NA

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