Bisindolylmaleimide XI Hydrochloride

Catalogue number: B448530
Chemical name: Bisindolylmaleimide XI Hydrochloride
Synonyms: 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride; Ro 31-0432;
CAS Number: 145333-02-4
Possible CAS #: NA
Molecular form.: C₂₈H₂₉ClN₄O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 489.01
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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