Bisindolylmaleimide VIII Acetic Acid Salt

Catalogue number: B448500
Chemical name: Bisindolylmaleimide VIII Acetic Acid Salt
Synonyms: 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Acetic Acid Salt; Ro 31-7549 Acetic Acid Salt; Ro 31-7549/001 Acetic Acid Salt;
CAS Number: 138516-31-1
Possible CAS #: Free Acid: 125313-65-7
Molecular form.: C₂₆H₂₆N₄O₄
Appearance: Red Solid
Melting Point: >135°C (dec.)
Mol. Weight: 458.51
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
Dangerous Goods Info: NA
References: Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),
Peer Review Product Citations:

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  Pack size Price(USD)
10mg $140.00
  Pack size Price(USD)
100mg $1120.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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