(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)

Catalogue number: B443810
Chemical name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
Synonyms: (1E,4E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one; 2-HBA; (E,E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one;
CAS Number: 131359-24-5
Possible CAS #: NA
Molecular form.: C₁₇H₁₄O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 266.29
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.
Dangerous Goods Info: NA
References: Perjesi, P. et al.: In Vivo, 20, 141 (2006); Magesh, S. et al.: Med. Res. Rev., 32, 687 (2012); Dinkova-Kostova, A.T. et al.: Cancer Lett., 245, 341 (2007);
Peer Review Product Citations:

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