Catalogue number: B419015
Chemical name: 1,3-Bis(2-chloroethyl)urea
Synonyms: 1,3-Bis(2-chloroethyl)urea; 1,3-Bis(2-chloroethyl)urea; NSC 36198; Carmustine Related Compound A
CAS Number: 2214-72-4
Possible CAS #: NA
Molecular form.: C₅H₁₀Cl₂N₂O
Appearance: White Solid
Melting Point: 121-124ºC
Mol. Weight: 185.05
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Mutagenesis Research Chemicals
Boiling Point: No Data Available
Applications: 1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine (C183875), an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.
References: Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),
Dangerous Goods Info: NA

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