(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Catalogue number: B416125
Chemical name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms: (αR)-α-methyl-3,5-bis(trifluoromethyl)-Benzenemethanol; (+)-(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol
CAS Number: 127852-28-2
Possible CAS #: NA
Molecular form.: C₁₀H₈F₆O
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 258.16
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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