(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid

Catalogue number: B415725
Chemical name: (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
Synonyms: [3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-12,16-heptadecadienoic Acid;
CAS Number: 193146-26-8
Possible CAS #: NA
Molecular form.: C₃₉H₇₁NO₆SSi₂
Appearance: Oil
Melting Point: No Data Available
Mol. Weight: 738.22
Storage: No Data Available
Solubility: Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
Stability: No Data Available
Category: Chiral Reagents
Boiling Point: No Data Available
Applications: An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells’ microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Dangerous Goods Info: NA
References: Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999), Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)
Peer Review Product Citations:

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Inventory Status:   Pending QC

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