BIRT 377

Catalogue number: B399710
Chemical name: BIRT 377
Synonyms: (5R)-5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-Imidazolidinedione;
CAS Number: 213211-10-0
Possible CAS #: NA
Molecular form.: C₁₈H₁₅BrCl₂N₂O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 442.13
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: BIRT 377 acts as a potent allosteric modulator of the lymphocyte function-associated antigen-1 (LFA-1) resulting in the attenuation of cellular inflammatory process. Reversibly inhibitos LFA-1 mediated binding of leukemia cells to ICAM-1, encoder of cell surface glycoproteins.
Dangerous Goods Info: NA
References: Fukudome, K. et al.: Int. j. Cancer., 52, 418 (1992);
Peer Review Product Citations:

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