7-(Benzyloxy)-1-methyl-1H-indazole-3-carboxylic Acid

Catalogue number: B286785
Chemical name: 7-(Benzyloxy)-1-methyl-1H-indazole-3-carboxylic Acid
Synonyms: 1-Methyl-7-(phenylmethoxy)-1H-indazole-3-carboxylic Acid
CAS Number: 133841-13-1
Possible CAS #: NA
Molecular form.: C₁₆H₁₄N₂O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 282.29
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: 7-(Benzyloxy)-1-methyl-1H-indazole-3-carboxylic Acid is an intermediate in the synthesis of 7-Hydroxy Granisetron (H942675), a metabolite of Granisetron (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor.
Dangerous Goods Info: NA
References: Bloomer, J., et al.: Brit. J. Clin. Pharmacol., 38, 557 (1994); Vernekar, S.,e t al.: J. Med. Chem., 53, 2324 (2010); Kilpatrick, G.J., et al.: Nature, 330, 746 (1987); Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997); Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996)
Peer Review Product Citations:

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