Catalogue number: B208265
Chemical name: (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
Synonyms: (+)-cis-1-Benzoyl-3-triethylsilyloxy-4-phenyl-2-azetidinone; (3R,4S)-1-Benzoyl-4-phenyl-3-(triethylsiloxy)azetidin-2-one; (3R,4S)-1-Benzoyl-4-phenyl-3-(triethylsilyloxy)azetidin-2-one
CAS Number: 149249-91-2
Possible CAS #: NA
Molecular form.: C₂₂H₂₇NO₃Si
Appearance: Transparent Oil
Melting Point: No Data Available
Mol. Weight: 381.54
Storage: No Data Available
Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is an intermedaite of 10-O-[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel (B207800), which is an impurity in the synthesis of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi’s sarcoma.
References: Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),
Dangerous Goods Info: NA

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  Pack size Price(USD)
50mg $150.00
250mg $575.00
  Pack size Price(USD)
100mg $250.00
500mg $1035.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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