BAY 11-7082

Catalogue number: B118790
Chemical name: BAY 11-7082
Synonyms: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; (E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; (E)-3-(p-Tolylsulfonyl)-acrylonitrile; BAY 11-7821; BAY 117821
CAS Number: 19542-67-7
Possible CAS #: NA
Molecular form.: C₁₀H₉NO₂S
Appearance: Off-White Solid
Melting Point: 129-131°C
Mol. Weight: 207.25
Storage: Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Apoptosis, Aromatics, Inhibitors, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: BAY 11-7082 is a nuclear factor-κB (NF-κB) inhibitor and a potential anti-inflammatory agent. It selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of Iκβα without affecting constitutive Iκβα phosphorylation.
Dangerous Goods Info: NA
References: Pierce, J.W., et al.: J. Biol. Chem., 272, 21096 (1997); Keller, S.A., et al.: Blood, 96, 2537 (2000); Remacle-Bonnet, M.M., et al.: Cancer Res., 60, 2007 (2000); Thévenod, F., et al.: J. Biol. Chem., 275, 1887 (2000); Petegnief, V., et al.: Neuroscience, 104, 223 (2001); Kauppinen, T.M., et al.: J. Immunol., 174, 2288 (2005)
Peer Review Product Citations:

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  Pack size Price(USD)
5mg $45.00
25mg $130.00
  Pack size Price(USD)
10mg $65.00
50mg $225.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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