Atractyloside Calcium Salt

Catalogue number: A794540
Chemical name: Atractyloside Calcium Salt
Synonyms: (2β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₃₀H₄₃Ca₁.₅O₁₆S₂
Appearance: Pale Yellow Solid
Melting Point: 226-229°C (dec.)
Mol. Weight: 783.9
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Apoptosis, Heterocycles, Inhibitors, Chelating Agents & Ligands, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium
Boiling Point: No Data Available
Applications: Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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