Catalogue number: A780102
Chemical name: rac-AS-703026-d5
Synonyms: N-[(2R,S)-2,3-Dihydroxypropyl-d5]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;
CAS Number: 1794960-29-4
Possible CAS #: 1236699-92-5-unlabelled
Molecular form.: C₁₅H₁₀D₅FIN₃O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 436.23
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Labelled AS703026 (A780100). AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.
References: Billadeau, D., et al.: Cancer Res., 55, 3640 (1995), Kolch, W., et al.: Biochem. J., 351, 289 (2000), Smith, M., et al.: Leukemia, 17, 274 (2003), Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2008),
Dangerous Goods Info: NA

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