A77 1726

Catalogue number: A771726
Chemical name: A77 1726
Synonyms: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M; Teriflunomide
CAS Number: 163451-81-8
Possible CAS #: NA
Molecular form.: C₁₂H₉F₃N₂O₂
Appearance: White Solid
Melting Point: 229-232°C
Mol. Weight: 270.21
Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility: DMSO, Methanol (Sparingly)
Stability: No Data Available
Category: Metabolites & Impurities, Tyrosine Kinase Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). 
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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