A77 1726 (E/Z) Mixture

Catalogue number: A771720
Chemical name: A77 1726 (E/Z) Mixture
Synonyms: 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide; 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; rac-Teriflunomide; USP Leflunomide Related Compound B;
CAS Number: 108605-62-5
Possible CAS #: NA
Molecular form.: C₁₂H₉F₃N₂O₂
Appearance: White Solid
Melting Point: 228-230°C (dec.)
Mol. Weight: 270.21
Storage: Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility: DMSO, Methanol (Sparingly)
Stability: No Data Available
Category: Metabolites & Impurities, Tyrosine Kinase Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). 
Dangerous Goods Info: NA
References: Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)
Peer Review Product Citations: Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)

Order Product

  Pack size Price(USD)
50mg $75.00
1g $880.00
  Pack size Price(USD)
100mg $110.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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