1-β-D-Arabinofuranosyluracil-2-C-methyl

Catalogue number: A764005
Chemical name: 1-β-D-Arabinofuranosyluracil-2-C-methyl
Synonyms: 1-(2-C-Methyl-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; Sofosbuvir Impurity 12
CAS Number: 114262-49-6
Possible CAS #: NA
Molecular form.: C₁₀H₁₄N₂O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 258.23
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Carbohydrates & Derivatives, Heterocycles, Impurities, Nucleotides, Bases & Related Reagents
Boiling Point: No Data Available
Applications: 1-β-D-Arabinofuranosyluracil-2-C-methyl is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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